Although the primary type of cultures in biopharmaceuticals nowadays is suspension cell cultures, many cell lines can’t prosper in a suspension (e.g. Sf9 insect epithelial cells, HEK 293 cells). These cells are called adherent cells and can only survive and grow when they are attached to a surface, either the bottom of a flask or some other type of anchor.

Even the now-very-popular suspension cells, the CHO (Chinese hamster ovary) cells, were once adherent cells but were adapted to be cultured in suspensions in stirred tank bioreactors. But some cells can’t adapt to survive in a suspension and therefore need to be cultured in adherent cell bioreactors.

We offer two types of adherent cell bioreactors, running on the Tide Motion principle. The Tide Motion principle is based on the oscillation of culture medium into and out of the matrix vessel, interchangeably exposing the cells to aeration and nutrition, while washing away products and waste. It produces no air bubbles and causes extremely low shear stress, which can both be harmful to the cells.

CelCradle

The CelCradle is capable of high-density cell culturing for virus and mAb production and protein expression. It is based on the concept of below-induced interchanging flow of media and air through porous matrices to which the cells are anchored. This provides a high-aeration, foam-free, and low-shear culture environment.

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TideXcell

TideXcell is a linearly scalable system, ideal for biomass expansion of adherent cells with single-use or multi-use technologies. The TideXcell is equipped with its own cell harvesting system, capable of achieving a > 90% recovery rate.

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If you need help deciding which adherent cell bioreactor to go with, send us an email to This email address is being protected from spambots. You need JavaScript enabled to view it. or contact us by filling out the form below.

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