xCubio in-situ

SIP/CIP systems for high-end and scaled applications

For a high sensitivity level of work, a sterilised, secure, and reliable bioreactor or fermenter system is a must. It has to comply with GMP-guidelines as well as other standards.

The challenge with sterilisation is the supply of steam and/or cleaning detergents to all parts that are in contact with the media, exposing them to these conditions over a period of time.

The xCUBIO in-situ performs the required CIP (clean-in-place) and SIP (sterilise-in-place) processes safely and reliably. It can be fully automated, thus making the sterilisation and cleaning reproducible and your pilot bioprocess optimised.

xCUBIO in-situ at a glance

  • Reliable and reproducible sterility
  • Almost dead-volume-free
  • Standard systems with 5, 10, 20, 30, or 50 litres
  • Additional sizes are possible for customised projects of up to 15 m³ operating volume (for more info, check our Industrial bioreactors section)
  • Stand-alone bioreactors or integrated installations
  • Qualification-ready, validation supported
  • Most flexible equipment selection: automation, sensors, gassing

Options and equipment

  • Compact skid installation, mobile, even as a twin bioreactor system
  • Certified stainless steel vessels
  • Up to 10 internal media pumps
  • Arbitrary external pumps or other drives
  • Most complex gassing regimes with full-grade MFC-control
  • Complete inline sensors selection
  • Automatic sampling, analysis, and result feedback (PAT) with bioPROBE
  • Integrated or external steam generators

Automation and control

  • 19″ touch display, additional local terminals on demand
  • Complete system display in a well-arranged presentation
  • Intuitive operation with a pleasant user interface
  • Powerful trend display with an analysis tool
  • Flexible sequence editor for arbitrary user-specific processes
  • Integration into superior process software via open platform communications
  • Software adaptation to every user demand
  • Value-logging and GMP-compliant storage

The xCUBIO enables the supply of qualified bioreactor installations for validated pilot-production bioprocesses, achievable through engineering, procurement, mounting, and testing trials with all the compiled necessary documentation.

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If you are interested in the bbi-biotech’s xCUBIO in-situ pilot bioreactor, contact us at This email address is being protected from spambots. You need JavaScript enabled to view it..

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